Different music servers

I realise LMS is a popular music server and I’ve been reading up on alternative ones like Moode and Volumino. Many folks suggest everything else being equal (e.g. hardware) the sound from other servers seem better. Now if it’s bit perfect to to each server, can software really introduce differences, especially of the file is played native i.e. Flac, ALAc etc

I’m not convinced in theory - not experimented myself yet. Just wondered if anybody has experience?